Research areas
I am interested in the structure and function of eukaryotic carbohydrate processing enzymes. Obtaining a greater appreciation of how these enzymes assimilate or degrade carbohydrates is important in understanding the biological roles that carbohydrates play in cellular processes, and also how these processes malfunction in a number of diseases, such as cancer, lysosomal storage disorders, and neurodegenerative diseases.
I am currently investigating the enzymes responsible for the degradation of heparan sulphate, a component of the extracellular matrix. Using a combination of approaches, including molecular biology, protein production, X-ray crystallography, enzyme kinetics and cell culture, I aim to gain a greater understanding of these enzymes from a mechanistic and structural perspective. Hopefully this will lead to the development of tools, such as enzyme inhibitors, that can be used to probe the biological functions of the enzymes, and possibly also for therapeutic applications in the longer term.
PhD supervision
- MishaÌýAtkinson
- PeterÌýBlack
- StuartÌýMcQuarrie
- BrendonÌýMedley
Selected publications
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Open access
Chi, H., Hoikkala, V., McMahon, S., Graham, S., Gloster, T. & White, M., 23 Jan 2026, In: Nature Communications. 17, p. 1-10 10 p., 889.
Research output: Contribution to journal › Article › peer-review
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Open access
Orzechowski, M. G., Hoikkala, V., Chi, H., McMahon, S., Gloster, T. & White, M., Nov 2025, In: Biochemical Journal. 482, 22, p. 1-13 13 p., BCJ20253271.
Research output: Contribution to journal › Article › peer-review
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Gloster, T. M. & Toksoy Öner, E., 1 Dec 2025, In: FEBS Letters. 599, 23, p. 3417-3443
Research output: Contribution to journal › Review article › peer-review
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Athukoralage, J. S., McMahon, S. A., Zhang, C., Grüschow, S., Graham, S., Krupovic, M., Whitaker, R. J., Gloster, T. M. & White, M. F., 17 Apr 2025, In: Nature. 640, 8059, p. E15-E17 3 p.
Research output: Contribution to journal › Comment/debate › peer-review
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Open access
Chi, H., McMahon, S., Daniel-Pedersen, L., Graham, S., Gloster, T. M. & White, M. F., 22 Jul 2025, In: Nucleic Acids Research. 53, 13, p. 1-11 11 p., gkaf655.
Research output: Contribution to journal › Article › peer-review
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Open access
Grüschow, S., McQuarrie, S., Ackermann, K., McMahon, S., Bode, B., Gloster, T. & White, M., 12 Apr 2024, In: Nucleic Acids Research. 52, 6, p. 2761-2775 15 p., gkae167.
Research output: Contribution to journal › Article › peer-review
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Open access
McQuarrie, S., Athukoralage, J. S., McMahon, S. A., Graham, S., Ackermann, K., Bode, B. E., White, M. F. & Gloster, T. M., 27 Oct 2023, In: Nucleic Acids Research. 51, 19, p. 10590-10605 16 p.
Research output: Contribution to journal › Article › peer-review
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Open access
Hobbs, E. E. M., Gloster, T. & Pritchard, L., 14 Aug 2023, In: Microbial Genomics. 9, 8, 23 p., 001086.
Research output: Contribution to journal › Article › peer-review
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Open access
Hobbs, E. E. M., Gloster, T. M. & Pritchard, L., 3 Dec 2022, bioRxiv, 19 p.
Research output: Working paper › Preprint
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Open access
Sweeney, P., Galliford, A., Kumar, A., Raju, D., Krishna, N. B., Sutherland, E., Leo, C. J., Fisher, G., Lalitha, R., Muthuraj, L., Sigamani, G., Oehler, V., Synowsky, S. A., Shirran, S. L., Gloster, T., Melo Czekster, C., Kumar, P. & da Silva, R. G., May 2022, In: Journal of Biological Chemistry. 298, 6, 15 p., 102040.
Research output: Contribution to journal › Article › peer-review
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